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The Entourage Effect

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As CBD continues to grow in popularity, so too does our understanding of its mechanisms and how it interacts with our bodies.
One of the most fascinating concepts is the entourage effect,
which has been found to enhance the therapeutic effects of CBD.


In this article, we’ll explore the entourage effect in depth, specifically for new CBD users. We’ll explain what the entourage effect is and how it works, along with the benefits it can offer. We’ll also provide tips on how to achieve the entourage effect, including choosing the right type of CBD product.

By the end of this article, you’ll have a clear understanding of the entourage effect and how it can impact your experience with CBD products.

So, whether you’re new to the world of CBD or a seasoned user,
keep reading to learn more about this fascinating phenomenon.

What Is The Entourage Effect?

The entourage effect is a phenomenon that describes the synergistic relationship between the different compounds present in
cannabis, namely cannabinoids, terpenes, and flavonoids.
This concept proposes that these compounds work together to enhance the overall effects of cannabis.

Cannabinoids, including THC and CBD, are the most well-known compounds in cannabis, with THC being responsible for the psychoactive effects of cannabis and CBD being studied for its potential therapeutic benefits.

Terpenes, on the other hand, give cannabis its unique aroma and flavor, while also contributing to its effects.
Some terpenes have been shown to possess anti-inflammatory, anti-anxiety, and pain-relieving properties.

Flavonoids, although less studied, are known to have antioxidant and anti-inflammatory effects.

The entourage effect occurs when these compounds collaborate to produce more potent and well-rounded effects.
For instance, the calming effects of CBD can counteract the psychoactive effects of THC when they are used together.

Also, certain terpenes can enhance the effects of cannabinoids by increasing their absorption in the body.

The concept of the entourage effect is supported by scientific research.
A 2011 study published in the British Journal of Pharmacology showed that the combination of CBD with other cannabinoids and terpenes was more effective in reducing inflammation.

Similarly, a 2018 study published in Frontiers in Plant Science demonstrated that the combination of different cannabinoids and
terpenes produced a more potent anti-inflammatory effect than when used individually.

Does The Entourage Effect Apply To CBD Hemp-Derived Products?

When it comes to CBD products, there are two main sources: hemp and marijuana. While both plants belong to the cannabis family, they have different chemical compositions.

Hemp-derived CBD products are made from hemp plants that contain less than 0.3% THC.

THC is the psychoactive compound that gives cannabis its intoxicating effects. There are many hemp-derived CBD products that are full-spectrum,

meaning they contain a variety of cannabinoids, terpenes and flavonoids.
Marijuana-derived CBD products, on the other hand, are made from marijuana plants that contain higher levels of THC.

These products are often used for medicinal or recreational purposes in countries where cannabis is legal.

So, does the entourage effect apply to hemp-derived CBD products? The answer is yes.

The entourage effect refers to the synergistic interaction between different compounds found in the cannabis plant,
and CBD products derived from hemp contain a variety of these compounds.

The entourage effect also applies to hemp-derived CBD products due to their full-spectrum nature.
The combination of cannabinoids, terpenes and flavonoids enhances the therapeutic effects of CBD, providing a more significant overall effect.

Scientific evidence supports the idea of the entourage effect,
emphasizing the importance of using full-spectrum CBD products for maximum therapeutic benefits.

What Are The Benefits Of The Entourage Effect? 

Now that we understand what is the entourage effect,
let’s explore the potential benefits it can offer CBD consumers.

The entourage effect is the result of the synergistic relationship between the various compounds found in cannabis. Here are some of the benefits of the entourage effect:

      • Enhanced therapeutic effects: By working together, cannabinoids, terpenes, and flavonoids produce more potent and well-rounded effects than they would on their own.
        This means that hemp-derived CBD products with a full spectrum of compounds are more effective in treating certain
        conditions than products containing only CBD isolate.

      • Balanced psychoactive effects: The presence of CBD can counteract the psychoactive effects of THC,
        making cannabis products more tolerable for those who experience anxiety or paranoia when using THC on its own.

      • Increased bioavailability: The presence of certain terpenes can enhance the effects of cannabinoids by increasing their absorption in the body.
        This means that the effects of cannabis can be felt more quickly and last longer.

      • More personalized effects: Different ratios of cannabinoids and terpenes can produce different results,
        which allows for a more personalized cannabis experience based on individual needs and preferences.

      • Better overall experience: The entourage effect is what gives cannabis its unique effects and flavors.
        By experiencing the full spectrum of compounds, users can enjoy a more well-rounded and enjoyable cannabis experience.

    In conclusion, the entourage effect offers many benefits for cannabis users, including enhanced therapeutic effects, balanced psychoactive effects, increased bioavailability, more personalized effects, and a better overall experience.

    When choosing hemp-derived CBD products, it’s important to consider the entourage effect and opt for full-spectrum products to maximize the potential benefits.

    How to Achieve the Entourage Effect

    The entourage effect is a desirable outcome for those seeking the maximum therapeutic benefits of CBD.
    It’s achieved through the synergistic interaction of the different compounds found in the cannabis plant.
    Among these compounds are cannabinoids, terpenes, and flavonoids,
    which work together to enhance the overall effects of CBD.

    There are different types of CBD products available on the market, including:

        • Full-spectrum: Contains all the compounds found in the cannabis plant, including THC (up to 0.3%).

        • Broad-spectrum: Contains all the compounds found in the cannabis plant, except for THC

        • IsolateContains only CBD and doesn’t contain any other compounds.

      The type of CBD product you choose can affect the entourage effect.
      Full-spectrum CBD is believed to have the most potent entourage effect because it contains all the compounds found in the cannabis plant, including THC.

      The THC in full-spectrum CBD can enhance the effects of CBD and other compounds, resulting in a more potent and well-rounded experience.
      However, some people may be sensitive to THC and may prefer to use broad-spectrum or isolate CBD instead.

      When choosing a CBD product to achieve the entourage effect,
      it’s essential to consider your individual needs and preferences.
      If you don’t mind the presence of THC and want to experience the maximum therapeutic benefits of CBD, full-spectrum CBD may be the best option for you. On the other hand, if you want to avoid THC altogether, broad-spectrum or isolate CBD may be a better choice.

      It’s also important to do your research and choose a reputable CBD brand that uses high-quality, third-party-tested ingredients.
      This will ensure that you’re getting a safe and effective CBD product that can help you achieve the entourage effect and experience the maximum therapeutic benefits of CBD.

      Full Spectrum CBD Oil vs CBD Isolate: Differences and benefits

      CBD Extract TypeDescriptionCBD ContentTHC ContentCharacteristicsBest for
      Full SpectrumContains all the compounds found in the hemp plant, including CBD, terpenes, flavonoids, and other cannabinoidsHigh levels of CBD and low levels of THC0.3%Offers the full range of hemp plant benefits, including the entourage effect.Those looking for a product containing all of the compounds found in hemp plants
      Broad SpectrumContains CBD, terpenes, and other cannabinoids, but has had the THC removed High0%Provides the benefits of the hemp plant without the psychoactive effects of THC.Those who want a product containing CBD without THC
      IsolateContains only pure CBD, with no other hemp plant compounds High0%Offers the benefits of CBD without any other hemp plant compounds.Those who want a product containing only CBD

      The Bell-Shaped Theory

      The Bell-Shaped Theory is a concept in pharmacology that suggests that the response to a drug does not have a linear relationship with dosage,
      but rather has an optimal range, beyond which the response decreases or becomes ineffective.

      This theory applies to CBD, where there is an optimal dosage range for achieving therapeutic benefits.

      A recent study conducted by the Hebrew University in Jerusalem provides further insight into this concept.

      The study observed two sets of mice, where one set received CBD isolate, while the other set received whole plant extracts of a full spectrum CBD.

      The results showed that the mice that received CBD isolate demonstrated a bell-shaped response, indicating that the effect peaked at a specific dosage and became less effective with doses smaller or larger than the optimal.

      However, this was not the case with the mice that received the extract with traces of other cannabinoids.

      The full spectrum extract had better efficacy than the isolate,
      suggesting that the entourage effect can overcome the bell-shaped dose-response curve of CBD isolate.

      This study highlights the importance of using full-spectrum or broad-spectrum CBD products over CBD isolate for achieving optimal therapeutic benefits.

      CBD isolate products may not provide the same level of effectiveness as products that contain other cannabinoids, terpenes, and flavonoids
      that work synergistically to enhance the therapeutic benefits of CBD.

      Minor Cannabinoids: Meet CBD’s Helpful Friends

      Minor cannabinoids are cannabinoids that occur in smaller quantities in the cannabis plant compared to THC and CBD.

      These lesser-known cannabinoids, such as CBG, CBN, and CBC, play an important role in the entourage effect.

      When combined with CBD and other cannabinoids,
      these minor cannabinoids work synergistically to enhance the overall therapeutic benefits of the plant.

      Each of these minor cannabinoids also has unique benefits,
      making them an important area of study for researchers and cannabis enthusiasts alike.

      CBG: The Mother of All Cannabinoids

      CBG, also known as cannabigerol, is a minor cannabinoid found in small amounts in most cannabis strains.

      It’s often referred to as the “mother cannabinoid” because all other cannabinoids start as CBG.

      In recent years, hemp breeders have been developing strains with higher levels of CBG, some with up to 16% CBG.

      Studies have suggested that CBG may have several potential health benefits.

      One area of interest is its potential cognitive support and brain health benefits.
      CBG has been shown to promote neurogenesis, the growth of new brain cells,
      which may play a role in the treatment of neurological conditions such as Alzheimer’s disease and Parkinson’s disease.

      CBG has also demonstrated antidepressant properties in animal studies,
      suggesting it may have potential as a natural alternative to traditional antidepressant medication.

      In addition, CBG has been shown to have anti-inflammatory, antifungal and antibacterial properties, making it a promising option for treating bacterial infections and skin conditions.

      It’s important to note that more research is needed to fully understand the potential health benefits of CBG. However, with the growing interest in minor cannabinoids and the entourage effect, CBG is becoming an increasingly popular topic of research.

      CBN: The cannabinoid that makes you sleepy

      CBN or cannabinol is another minor cannabinoid that is gaining popularity for its potential sleep-enhancing properties.

      Cannabinol (CBN) is formed when THC is exposed to air and light over time.
      This is why old cannabis flowers contain higher levels of CBN than fresh flowers.

      CBN is known to interact with the body’s endocannabinoid system (ECS) by binding to CB1 and CB2 receptors,
      which can help promote sleep and relaxation.
      CBN is often referred to as “the cannabinoid that makes you sleepy” because it is believed to have sedative effects,
      making it a popular choice for people with sleep problems.

      In addition to its sedative effects, CBN has also been studied for its potential pain-relieving properties.
      A 2019 study in rats found that CBN, combined with CBD, was effective in reducing pain.
      This suggests that CBN may have the potential for treating conditions such as chronic pain disorders and fibromyalgia.

      Another area of research is the potential neuroprotective effects of CBN.
      One study in rats found that CBN was able to delay the onset of amyotrophic lateral sclerosis (ALS).

      Although this research is still in its early stages, it suggests that CBN may hold promise as a neuroprotective compound.

      Additional research suggests that CBN may also have anti-inflammatory effects.
      One study in rats found that CBN was effective in reducing inflammation caused by arthritis.

      CBC: The cannabinoid with anti-inflammatory properties

      CBC, or cannabichromene, is a minor cannabinoid found in the cannabis plant.
      While CBC is present in smaller amounts compared to THC and CBD,
      it has its own unique properties and potential health benefits.

      One of the most notable benefits of CBC is its anti-inflammatory properties.
      Studies have shown that CBC may help to reduce inflammation in the body,
      making it a potentially useful compound for conditions such as arthritis and other inflammatory diseases.

      CBC has also been found to have pain-relieving effects.
      One study conducted on mice found that CBC was effective in reducing pain and inflammation,
      and had a longer duration of action compared to CBD.

      Additionally, CBC has been found to have the potential in treating depression and stress.
      In one study, CBC was shown to increase the activity of receptors in the brain that regulate mood and emotions,
      suggesting that it may have antidepressant effects.

      Overall, while more research is needed to fully understand the potential benefits of CBC,
      its unique properties make it an interesting cannabinoid to study and explore.

      The Difference Between CBG, CBN, and CBC

      To better understand their individual effects and synergistic potential,
      let’s look at a table comparing CBG, CBN, and CBC:

      CannabinoidDefinitionOccurrence in CannabisPotential BenefitsIntoxicating Effects
      CBGCannabigerolPresent in small amounts, with some strains having up to 16% CBGAntifungal properties, helps to combat bacterial growth, shows potential as an antidepressant, cognitive support, promotes growth of new brain cells, non-intoxicatingNone
      CBNCannabinolBreakdown product of THC, higher levels in old cannabis flowersPromotes better sleep, helps to sedate the body, reduces pain and nausea, supports relaxation with minimal intoxicating effectsMinimal
      CBCCannabichromenePresent in small amounts in many cannabis plantsStrong anti-inflammatory properties, effective for pain relief, promotes growth of new brain cellsNone

      Terpenes and Flavonoids: What Are They and What Do They Do?

      While cannabinoids are the most well-known compounds in cannabis,
      they’re not the only ones that contribute to the plant’s effects.

      Terpenes and flavonoids are also important players in the entourage effect.
      The combination of flavonoids and terpenes in the cannabis plant creates a synergy that provides therapeutic benefits
      along with unique flavors and scents.

      Terpenes: The Molecules Responsible For Taste & Smell

      The terpenes are some of the most important molecules in the cannabis plant and play an essential role in the entourage effect.

      These organic compounds are found in many plants and herbs and contribute to the unique aroma and flavor of each species.

      In cannabis, terpenes are generally found in the trichomes, which are tiny, egg-shaped structures on the flower’s surface.

      There are hundreds of different terpenes, each with its own unique scent, flavor, and benefits.

      Some of the most common terpenes are limonene, myrcene, linalool and pinene.

      Check our most popular terpenes table to learn more about benefits and their effects:

      TerpeneAromaOccurrence in PlantsPotential Benefits
      🌿 MyrceneMusky, earthy, herbalFound in many plants including mangoes, hops, bay leaves, thymePromotes relaxation, pain relief, improved sleep, sedation
      🍋 LimoneneCitrusy, lemon-likeFound in citrus fruits such as lemons, limes, and orangesStress relief, anti-anxiety, improved mood, antifungal properties
      🌲 PineneFresh, pine-likeFound in pine trees and other coniferous plants, as well as rosemary and basilImproved memory and alertness, anti-inflammatory, antibacterial
      🌶️ CaryophyllenePeppery, spicy, woodyFound in black pepper, cinnamon, cloves, and hopsPain relief, anti-inflammatory, stress relief, anxiolytic (anti-anxiety) effects
      💐 LinaloolFloral, spicy, woodyFound in lavender, coriander, and basilStress relief, improved sleep, pain relief, anxiolytic (anti-anxiety) effects
      🍎 TerpinoleneFresh, floral, herbalFound in tea tree, conifers, apples, and cuminAntioxidant, improves alertness and energy, reduces stress, antimicrobial properties

      Flavonoids: The Compounds Responsible For Color

      Flavonoids are a diverse class of plant pigments that give color to many fruits, vegetables, and flowers.
      They are found in a wide variety of plants, and they play important roles in plant biology, including attracting pollinators and providing protection against pests and UV radiation.

      In cannabis, flavonoids are primarily found in the trichomes, along with cannabinoids and terpenes.
      The most abundant flavonoids in cannabis are quercetin, kaempferol, and apigenin.
      Quercetin has been shown to have antioxidant and anti-inflammatory properties, while kaempferol has been linked to anti-cancer effects.
      Apigenin, on the other hand, has been found to have anxiolytic (anti-anxiety) properties.

      Like terpenes, flavonoids are believed to contribute to the entourage effect,
      enhancing the effects of cannabinoids like CBD and THC.

      Some studies have also suggested that flavonoids may have therapeutic potential on their own, particularly in the areas of cancer and inflammation.

      It’s important to note that the specific flavonoid content of a given cannabis strain can vary depending on factors like growing conditions and harvesting methods.

      However, as with terpenes, it’s likely that the combination of flavonoids and other compounds in the cannabis plant work together to create the unique therapeutic effects of each strain.


          • The entourage effect is a powerful phenomenon that occurs when cannabinoids, terpenes and flavonoids
            work together to enhance the overall effects of cannabis.

          • Research has shown that this combination of compounds can enhance the overall effects of cannabis,
            providing more potent and well-rounded effects than when used alone.

          • Full-spectrum CBD products are believed to have the most potent entourage effect,
            providing enhanced therapeutic effects, balanced psychoactive effects, and a better overall experience.

          • Minor cannabinoids such as CBG, CBN, and CBC also contribute to the entourage effect
            by working together with CBD to enhance its therapeutic benefits.

          • Terpenes and flavonoids are organic compounds found in the trichomes of the cannabis plant that may enhance the effects of cannabinoids like CBD and THC and have potential therapeutic benefits on their own.

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